SR9009, also known as Stenabolic, is a synthetic medication created to examine the circadian rhythm. It was shown to improve endurance, decrease anxiety, and reduce cholesterol, weight, and inflammation. These impacts, if shown in people, would repeat some of those valuable effects exercise has on our bodies. However, Stenabolic hasn’t yet been examined in people at all! Its side effects can also be unknown. Keep reading to learn why it’s harmful.
Disclaimer: We highly recommend against using this drug since its effects and safety are totally unknown. No human information on it’s been printed so far. Thus, we are presenting the available information from the scientific literature with the aim of helping readers understand the risks involved.
About SR9009 (Stenabolic)
What is it exactly?
Stenabolic or SR9009 is a research compound. So far, no human studies on the usage of SR9009 have been published.
Thus, we don’t know how dangerous this substance could be. Its effectiveness in humans is also unknown. This means it has a higher potential for injury and should be avoided in any way costs.
Our bodies function in a coordinated manner, in 24-hour cycles which are corrected to the rise and collapse of the sunlight. This pattern is known as the circadian rhythm.
The circadian rhythm is preserved via a loop mechanism that turns genes on and off (when CLOCK and BMAL1 genes are turned on, they flip on PER and CRY. Then, PER/CRY turn BMAL1/CLOCK off along with also the 24-hour cycle resets).
The REV-ERBs really are a pair of proteins that stabilize our inner clock by turning BMAL1 off. They are, in turn, activated from the heme group. Heme is a little iron-containing chemical found all through the entire body, for example, in red blood cells.
SR9009 is a chemical that enhances REV-ERB activity (called agonists) and has good bioavailability.
Due to the numerous positive effects found in animals, SR9009 found its way online and is being sold and utilized as a nutritional supplement, mainly within the bodybuilding community. It has been known as”exercise in a jar.” But, there is still a lot of things we do not understand about this medication, including its side effects.
Mechanism of Action
All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the human body.
REV-ERB impacts the circadian behavior of mice, changing their activity and sleep patterns.
Apart from its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB influences many different functions associated with energy generation.
REV-ERB is mainly found in liver, muscle, and fat tissue:
- Liver: REV-ERB impacts the rhythm of 90 percent of the about 900 genes under circadian control in mice liver. It ends the genes which produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory reaction (by changing macrophage production).
- Muscles: REV-ERB promotes the burning of fat, raises the activity of mitochondria, and promotes the creation of fresh whilst diminishing the devastation of older mitochondria.
- Fat cells: REV-ERB turns off the enzymes responsible for storing fat and decreases triglyceride production.
In animal and cell studies, SR9009:
- Increased oxygen consumption
- Reduced production of fresh fat cells from the liver
- Decreased production of cholesterol and bile acids in the liver
- Increased the number of mitochondria in muscle
- Increased sugar and fatty acid use in muscle
- Reduced fat storage
1) Weight Loss
Mice injected with SR9009 for 2 days shed weight because of a decline in fat mass. Food intake wasn’t influenced.
Similarly, diet-induced obese mice injected with SR9009 for 30 days lost 60% more fat than control animals. Blood levels of triglycerides, total cholesterol, free fatty acids, and insulin levels also decreased.
In genetically obese mice, SR9009 ceased weight reduction after 12 times without affecting glucose levels or insulin tolerance.
2) Blood Cholesterol
SR9009 given for 2 to 10 days reduced blood levels of triglycerides and total cholesterol in mice.
Genetically altered mice getting a high cholesterol diet to acquire a fat profile much like humans were awarded SR9009 for 8 weeks. Total cholesterol and triglycerides have been similarly reduced, whilst LDL cholesterol has been lowered but HDL cholesterol was unaffected.
Mice treated with SR9009 for 30 days showed improved endurance. They hurried for more time and covered more distance than controllers.
SR9009 increased the amount of total and active mitochondria in muscle tissues (by repressing autophagy genes).
4) Decreasing Inflammation
SR9009 diminished lung inflammation in rats (by reducing the creation of TNF-alpha).
Additionally, it reduced the generation of inflammatory compounds (CCL2, MMP-9) in rat neural cells.
5) Heart Disease
Genetically modified mice vulnerable to hardening of the arteries were treated with SR9009 for 7 weeks. The size of this blood vessel lesions was reduced, whilst food intake, body weight, and blood glucose levels weren’t affected.
In both the normal and genetically modified old mice, SR9009 recovered for 28 days improved heart function.
In mice using surgically induced heart development (hypertrophy), SR9009 given for 2 weeks reduced heart size and weight, with no effect on blood pressure.
As an activator of REV-ERB, S9009 affects sleep/wake patterns in mice. However, its effects are short-term and last only 12 hours.
Mice injected with SR9009 during daytime (that is when the mice are supposed to be asleep) were active during the daytime and had less profound sleep (less REM and slow-wave sleep). However, when SR9009 was recovered through the night (when mice are busy ), it had no impact.
SR9009 may potentially help in maintaining wakefulness once the drive for sleep is significant including shift work, jet lag, and a few sleep-related disorders.
SR9009 injected twice per day for 3 to 10 days, decreased anxiety-like behavior in mice and has been as effective as a benzodiazepine.
8) Tissue Damage (Fibrosis)
SR9009 decreased tissue damage in mice with induced liver scarring when medicated with SR9009 for two weeks.
The side effects of SR9009 are unknown. This medication has serious potential for injury. Taking could be terribly dangerous because its safety profile has not yet been researched.
So far, SR9009 has proven no liver toxicity in mice when used for up to 7 months.
Some users reported sleeplessness.
No human dosage has been established so far. Most experiments in mice have utilized a dose of 100 mg/kg applied intraperitoneally; which is injected directly into the body cavity.
Online bodybuilding forums, but suggest a much lower daily dose of 10-40 mg. They also indicate dividing this into 3-4 doses per day.
There are no scientific reports on the effectiveness of SR9009 when taken orally.
Limitations and Caveats
To date, no scientific studies on the use of SR9009 in humans have been published.
SR9009 is sold online for use as a performance enhancer in bodybuilding.
Some users report improved endurance, whilst others state it’s limited or no benefits. For many, the proposed repeated dosing (3-4 times daily ) makes it bothersome to use.
- “I believe it immediately. Together with SR9009, it’s like there’s this little”pop” of alertness. It can induce sleeplessness (which occurred to me) and may explain that”pop” like a flash of”it is daytime!”
- “I have used it a bit. The power and stamina gains are pretty pronounced.”
- “It gives really pleasant increases to endurance, but feels different than a traditional stimulant”
- “Didn’t feel much.”
You will find vendors who sell SR9009 in the United States.
We advise speaking to a doctor before taking any drug, especially an unscheduled medication with limited long-term safety information in humans.